Dclk1-IN-1

• Catalog Number: orb1818507
• Category: Small Molecules
• Description: DCLK1-IN-1 is a selective, oral bioavailability in vivo-compatible chemical probe of the doublecortin like kinase 1 (DCLK1 kinase) domain. DCLK1-IN-1 inhibits DCLK1 and DCLK2 kinases (IC50: DCLK1=9.5/57.2 nM and DCLK2=31/103 nM in binding and kinase assay, respectively). DCLK1-IN-1 shows low toxicity, and can investigate DCLK1 biology and establish its role in cancer, like DCLK1+ pancreatic ductal adenocarcinoma (PDAC)[1].
• CAS Number: [2222635-15-4]
• MW: 527.5414
• SMILES: FC(C([H])([H])N1C(C2=C([H])C([H])=C([H])C([H])=C2N(C([H])([H])[H])C2C1=C([H])N=C(N=2)N([H])C1C([H])=C([H])C(=C([H])C=1OC([H])([H])[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])=O)(F)F
• Formula: C₂₆N₇O₂F₃H₂₈
• Note: For research use only
• Expiration Date: 12 months from date of receipt.