DBPR211

• Catalog Number: orb251373
• Category: Small Molecules
• Description: CB1-IN-1 (BPRCB1184) is a peripherally restricted CB1R antagonist, with Ki of 0.3 nM and 21 nM for CB1R (EC50 = 3 nM) and CB2R, respectively. IC50 value: 0.3 nM (Ki, CB1R) 21 nM (Ki, CB2R) Target: CB1R in vivo: CB1-IN-1 is a novel peripherally restricted cannabinoid 1 receptor antagonist with significant weight-loss efficacy in diet-induced obese mice. CB1-IN-1 has great potential to ameliorate this related metabolic syndrome.
• CAS Number: [1429239-98-4]
• MW: 750.12
• SMILES: C1CCN(CC1)NC(=O)C2=NN(C(=C2CNS(=O)(=O)N3CCCC3)C4=CC=C(S4)C#CC5=CC=C(C=C5)C(F)(F)F)C6=C(C=C(C=C6)Cl)Cl
• Formula: C₃₃H₃₁Cl₂F₃N₆O₃S₂
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

Chemical structure of DBPR211