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DAPT

SKU: orb1225711

Description

DAPT (GSI-IX) is a novel γ-secretase inhibitor, which inhibits Aβ production with IC50 of 20 nM in HEK 293 cells.

Images & Validation

Key Properties

CAS Number208255-80-5
MW432.46
Purity>98% (HPLC)
FormulaC23H26F2N2O4
SMILESO=C(OC(C)(C)C)[C@H](C1=CC=CC=C1)NC([C@H](C)NC(CC2=CC(F)=CC(F)=C2)=O)=O
TargetGamma-secretase
SolubilityEthanol: 50 mg/mL (115.61 mM); DMSO: 86 mg/mL (198.86 mM)

Bioactivity

In Vitro
DAPT (GMP) (9 d) induces human induced pluripotent stem cells develop into expandable myoblasts. DAPT (GMP) (13 d) induces human pluripotent stem cells (hPSCs) develop into functional neurons.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

GSI-IX

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Protocol Information

DAPT (orb1225711)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO +
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% Tween 80 +
%

Available Sizes

Select a size below

500 mg
5 mg
$ 90.00
10 mg
$ 140.00
25 mg
$ 230.00
50 mg
$ 370.00
100 mg
$ 540.00
200 mg
$ 660.00