DAPT

SKU: orb1225711

Description

DAPT (GSI-IX) is a novel γ-secretase inhibitor, which inhibits Aβ production with IC50 of 20 nM in HEK 293 cells.

Key Properties

• CAS Number: 208255-80-5
• MW: 432.46
• Purity: >98% (HPLC)
• Formula: C₂₃H₂₆F₂N₂O₄
• SMILES: O=C(OC(C)(C)C)[C@H](C1=CC=CC=C1)NC([C@H](C)NC(CC2=CC(F)=CC(F)=C2)=O)=O
• Target: Gamma-secretase
• Solubility: Ethanol: 50 mg/mL (115.61 mM); DMSO: 86 mg/mL (198.86 mM)

Bioactivity

• In Vitro:
  DAPT (GMP) (9 d) induces human induced pluripotent stem cells develop into expandable myoblasts. DAPT (GMP) (13 d) induces human pluripotent stem cells (hPSCs) develop into functional neurons.
  Read more...

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GSI-IX

Quick Database Links

Gene Symbol

Gamma-secretase