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Catalog Number | orb1731039 |
---|---|
Category | Antibodies |
Description | This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Species/Host | Rabbit |
Clonality | Monoclonal |
Tested applications | IHC, IP, WB |
Reactivity | Human |
Isotype | Rabbit IgG |
Immunogen | A synthetic peptide of human DAB2 |
Concentration | 1mg/ml |
Dilution range | IP: 1/20; WB: 1/500-1/1000; IHC: 1/50-1/100 |
Conjugation | Unconjugated |
MW | Calculated MW: 82 kDa; Observed MW: 96 kDa |
Entrez | 1601 |
UniProt ID | P98082 |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Buffer/Preservatives | 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% rAlbumin |
Alternative names | DOC2; DOC-2 Read more... |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
ELISA, FC, ICC, IF, IHC, WB | |
Human, Monkey, Mouse, Rat | |
Rabbit | |
Polyclonal | |
Unconjugated |
ELISA, WB | |
Human, Monkey, Mouse, Rat | |
Rabbit | |
Polyclonal | |
Unconjugated |
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