Cynomolgus / Rhesus B7-H4 Protein

• Catalog Number: orb1149281
• Category: Proteins
• Description: V-set domain-containing T-cell activation inhibitor 1 (VTCN1) is also known as Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7H4, which belongs to the immunoglobulin superfamily and BTN/MOG family. VTCN1 contains two Ig-like V-type (immunoglobulin-like) domains. The expression of VTCN1 is up-regulated by IL6 and IL10 and is inhibited by GM-CSF and IL4 on antigen-presenting cells (APCs). VTCN1 / B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. VTCN1 involved in promoting epithelial cell transformation.
• Reactivity: Monkey
• Tag: C-10×His
• Form/Appearance: Powder
• Purity: 90%
• Conjugation: Unconjugated
• MW: 27.2 kDa
• Target: B7-H4
• Protein Sequence: XP_001103715.1
• Source: Cynomolgus / Rhesus macaque B7-H4 Protein, His Tag (orb1149281) is expressed from human 293 cells (HEK293). It contains AA Phe 29 - Ala 258 (Accession # F7B770-1).
• Expression System: HEK293
• Expression Region: Phe 29 - Ala 258
• Endotoxins: 1.0 EU per μg
• NCBI: XP_001103715.1
• Storage: -20℃
• Buffer/Preservatives: PBS, pH7.4
• Alternative names: B7-H4,VTCN1,B7S1,B7h.5
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 27.2 kDa. The protein migrates as 45-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.