Cynomolgus LILRB1 / CD85j / ILT2 Protein

• Catalog Number: orb1149296
• Category: Proteins
• Description: CD85 antigen-like family member J (CD85J) is also known as Leukocyte immunoglobulin-like receptor subfamily B member 1 (LILRB1 or LIR-1), Immunoglobulin-like transcript 2 (ILT-2), Monocyte/macrophage immunoglobulin-like receptor 7 (MIR7), which belongs to leukocyte immunoglobulin-like receptor (LIR) family. CD85J / LILRB1 Contains 4 Ig-like C2-type (immunoglobulin-like) domains. CD85J / LIR-1 is expressed predominantly on B-cells and monocytes. CD85J is receptor for class I MHC antigens and recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles and is also receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. CD85J / LILRB1 interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. CD85J / LILRB1 inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
• Reactivity: Monkey
• Tag: C-10×His
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 49.0 kDa
• Target: LILRB1
• Protein Sequence: XP_045236898.1
• Source: Cynomolgus LILRB1, His Tag (orb1149296) is expressed from human 293 cells (HEK293). It contains AA Gly 41 - His 474 (Accession # XP_045236898.1).
• Expression System: HEK293
• Expression Region: Gly 41 - His 474
• Endotoxins: 1.0 EU per μg
• NCBI: XP_045236898.1
• Storage: -20℃
• Buffer/Preservatives: PBS, pH7.4
• Alternative names: CD85J,LILRB1,CD85,ILT2,LIR1,MIR7
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 49.0 kDa. The protein migrates as 60-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.