Cyclotraxin B TFA

• Catalog Number: orb1981621
• Category: Small Molecules
• Description: Cyclotraxin B TFA, a cyclic peptide, is a highly potent and selective non-competitive inhibitor of TrkB, effectively impeding BDNF-triggered TrkB activity without altering BDNF binding affinity, with an IC50 of 0.30 nM. It crosses the blood-brain barrier, demonstrating analgesic and anxiolytic-like behavioral effects [1] [2] [3].
• Purity: 98.00%
• MW: 1314.39
• Formula: C₅₀H₇₄F₃N₁₃O₁₉S₃
• Biological Activity: Cyclotraxin B TFA, a cyclic peptide, serves as a highly potent and selective non-competitive inhibitor of TrkB, effectively impeding BDNF-triggered TrkB activity without altering BDNF binding affinity, evidenced by an IC50 of 0.30 nM. It is capable of crossing the blood-brain barrier, demonstrating analgesic and anxiolytic-like behavioral effects [1] [2] [3].
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.