Cycloheximide

• Catalog Number: orb322384
• Category: Small Molecules
• Description: Cycloheximide
• CAS Number: 66-81-9
• Purity: ≥98%
• MW: 281.35
• SMILES: CC1CC(C(=O)C(C1)C(CC2CC(=O)NC(=O)C2)O)C
• Formula: C₁₅H₂₃NO₄
• Chemical Name: [1S-[1αS*),3α,5β]]-4-[2-(3,5-Dimethyl-2-oxocyclo- hexyl)-2-hydroxyethyl]-2,6-piperidinedione
• Hazard Information: Chemical Hazard Code: Xn, T+, Repr., N, Mut. UN Number: UN number: 2811 Class: 6.1 Packing group: I Proper shipping name: Toxic solid, organic, n.o.s. (Cycloheximide) Reportable Quantity (RQ): Poison inhalation hazard: No
• Solubility (25°C): Soluble in chloroform, DMSO, acetone, methanol, or ethanol. Soluble in water to 20 mg/ml.
• Storage: Stability: Cycloheximide has been reported to be soluble up to 2% (w/v) in water (20 mg/ml).14 The powder will dissolve slowly in water and this process may be aided by mixing or sonication. More dilute solutions (5 mg/ml) may be prepared without sonication. Aqueous solution stability is pH dependent. Solutions are stable for several weeks in the pH range of 3 to 5, which is the range optimal for stability. For longer term solution storage, refrigeration is suggested. Solutions refrigerated over 18 months, retained 75% of the original activity.13 Solutions prepared in distilled water may be sterile filtered or autoclaved without serious loss of activity.13 Autoclaving of medium containing cycloheximide is not recommended. The sterile cycloheximide solution should be added to sterile broth or cooled, sterile, melted agar.13 Boiling for one hour at pH 7 destroys activity, but no loss of activity is observed after 15 minutes. Under acidic conditions (pH 2), activity is not destroyed after one hour of boiling.14 Under dilute alkali conditions, decomposition occurs rapidly in solution at room temperature with the formation of 2,4-dimethylcyclohexanone. 14°Cycloheximide is also soluble in most organic solvents, including ethanol, with the exception of saturated hydrocarbons.14. Storage Temp: 4°C
• Alternative names: Naramycin A, Actidione
• Note: For research use only
• Expiration Date: 12 months from date of receipt.