CUL3 antibody

• Catalog Number: orb66953
• Category: Antibodies
• Description: Rabbit polyclonal to CUL3.CUL3 is a component of a ubiquitin E3 ligase that is essential for mitotic division. CUL3 is a corecomponent of multiple cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligasecomplexes which mediate the ubiquitination and subsequent proteasomal degradation of targetproteins. As a scaffold protein, CUL3 may contribute to catalysis through positioning of the substrateand the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex isdependent on the neddylation of the cullin subunit and is inhibited by the association of thedeneddylated cullin subunit with TIP120A/CAND1 (By similarity). BCR(SPOP) is involved inubiquitination of BMI1/PCGF4, H2AFY and DAXX, and probably GLI2 or GLI3, as well as cyclin E andof cyclin D1.
• Species/Host: Rabbit
• Clonality: Polyclonal
• Tested applications: WB
• Reactivity: Human
• Immunogen: C-terminal region of human CUL3
• Dilution range: WB:1:1000-1:5000
• Purity: Affinity purification
• Conjugation: Unconjugated
• MW: 89
• UniProt ID: Q13618
• Storage: -20°C
• Buffer/Preservatives: 0.01% NaN3
• Alternative names: anti-CUL3 antibody,anti-Cullin3 antibody,anti-KIAA
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

Western blot analysis of total cell extracts from human 293T using CUL3 antibody