CTLA-4 Antibody / CD152

• Catalog Number: orb639605
• Category: Antibodies
• Description: This CTLA4 antibody is specific to the soluble form of the protein. CTLA4 (CD152) is a cell surface receptor that behaves as a negative regulator of the proliferation and the effector function of T cells. It contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.The novel finding that CTLA-4 molecule is expressed and functional on human tumor cells opens up the possibility of antitumor therapeutic intervention based on targeting this molecule.
• Species/Host: Mouse
• Clonality: Monoclonal
• Clone Number: L4P2F5.F10
• Tested applications: WB
• Reactivity: Mouse, Rat
• Isotype: Mouse IgG1, kappa
• Immunogen: Amino acids CENAPNRARM were used as the immunogen for the CTLA4 antibody.
• Dilution range: Western blot: 1-2ug/ml
• Purity: Protein G affinity chromatography
• Conjugation: Unconjugated
• Formula: 0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
• Hazard Information: This CTLA4 antibody is available for research use only.
• UniProt ID: P16410
• Storage: Store the CTLA4 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
• Buffer/Preservatives: 0.2 mg/ml with 0.1 mg/ml rAlbumin (US sourced), 0.05% sodium azide
• Note: For research use only
• Application notes: Optimal dilution of the antibody should be determined by the researcher.
• Expiration Date: 12 months from date of receipt.