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Catalog Number | orb1732468 |
---|---|
Category | Antibodies |
Description | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR) .Tissue specificity: Predominantly expressed in B and T lymphocytes. Highest levels in lung. Also expressed in brain, colon, heart, kidney, ovary, and prostate. Weak expression in liver, pancreas, muscle, small inTine, spleen and stomach. |
Species/Host | Rabbit |
Clonality | Monoclonal |
Tested applications | ICC, WB |
Reactivity | Human, Mouse, Rat |
Isotype | Rabbit IgG |
Immunogen | A synthetic peptide of human CRTC3 |
Concentration | 1mg/ml |
Dilution range | WB: 1/500-1/1000; ICC: 1/50-1/200 |
Conjugation | Unconjugated |
MW | Calculated MW: 67 kDa; Observed MW: 78 kDa |
Entrez | 64784 |
UniProt ID | Q6UUV7 |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Buffer/Preservatives | 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% rAlbumin |
Alternative names | TORC3; FLJ21868; CRTC3 Read more... |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
ELISA, FC, ICC, IF, IHC, WB | |
Human, Monkey | |
Rabbit | |
Polyclonal | |
Unconjugated |
ICC, WB | |
Human, Mouse, Rat | |
Rabbit | |
Monoclonal | |
Unconjugated |
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