CPI-455

SKU: orb15683

Description

CPI-455 is a specific, pan-KDM5 inhibitor with an IC50 of 10 nM for KDM5A. CPI-455 mediates KDM5 inhibition, elevates global levels of H3K4me3, and decreases the number of drug-tolerant persister cancer cells in multiple cancer cell line models treated with standard chemotherapy or targeted agents.

Key Properties

• CAS Number: 1628208-23-0
• MW: 314.7695
• Purity: >98%
• Formula: C₁₆H₁₅CLN₄O
• SMILES: Cl[H].O=C1C(=C(C2C([H])=C([H])C([H])=C([H])C=2[H])N=C2C(C#N)=C([H])N([H])N12)C([H])(C([H])([H])[H])C([H])([H])[H]

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only