CPI-1205

SKU: orb1298870

Description

CPI-1205

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 1621862-70-1
• MW: 518.57
• Purity: 99.70%
• Formula: C₂₇H₃₃F₃N₄O₃
• SMILES: [C@H](C)(N1C=2C(C(C(NCC3=C(OC)C=C(C)NC3=O)=O)=C1C)=CC=CC2)C4CCN(CC(F)(F)F)CC4
• Target: Histone Methyltransferase
• Solubility: DMSO:95 mg/mL (183.2 mM)

Bioactivity

• Target IC50:
  EZH2:0.002 μM
• In Vivo:
  CPI-1205 is a highly potent (biochemical IC50 = 0.002 μM, cellular EC50 = 0.032 μM) and selective inhibitor of EZH2. This compound demonstrates robust antitumor effects in a Karpas-422 xenograft model when dosed at 160 mg/kg BID.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CPI1205, CPI-1205, CPI 1205, Lirametostat, HistoneMethyltransferase, Histone Methyltransferase, EZH2

Compound Identifiers

PubChem CID

78320408