信号通路专题系列一：JAK/STAT信号通路

 

     The Janus Kinase / Signal Transducers and Activators of Transcription (JAK/STAT) pathway is an evolutionary conserved signaling cascade which mediates the response to cytokines and growth factors. Cellular responses to the activation of this pathway include proliferation, differentiation, migration, apoptosis and cell survival. JAK/STAT signaling is integral to homeostatic and developmental processes such as hematopoiesis, immune development, stem cell maintenance, organismal growth and mammary gland development.

        Janus激酶/信号转导子和转录激活子（JAK / STAT）途径是介导对细胞因子和生长因子的应答的进化保守信号级联。 对该途径活化的细胞应答包括增殖，分化，迁移，细胞凋亡和细胞存活。 JAK / STAT信号传导是稳态和发育过程（如造血，免疫发育，干细胞维持，机体生长和乳腺发育）不可或缺的组成部分。

      The pathway is activated upon binding of an extracellular ligand, usually comprising interferons or growth factors. This results in multimerization of the receptor subunits bringing two JAKs into close proximity and thus activating them through transphosphorylation. Activated JAKs phosphorylate STATs, which are latent transcription factors residing in the cytoplasm. The activated STATs dimerize and enter the nucleus, binding to specific enhancer sequences resulting in gene transcription. In theory JAK/STAT signaling cascade is a simple mechanism linking extracellular signals into a direct transcriptional response, however is complicated by interactions with other signaling pathways. The best characterized are Ras/MAPK, PI3K and TGF-β.

        该途径在结合通常包含干扰素或生长因子的细胞外配体时被激活。 这导致受体亚基多聚化，使两个JAK紧密靠近并因此通过转磷酸化激活它们。 激活的JAKs磷酸化STAT，它们是位于细胞质中的潜伏转录因子。 活化的STATs二聚化并进入细胞核，与特定的增强子序列结合，导致基因转录。 理论上JAK / STAT信号级联是将细胞外信号连接成直接转录应答的简单机制，但是通过与其他信号传导途径的相互作用而复杂化。 最好的特征靶标是Ras / MAPK，PI3K和TGF-β。

 

 

帮助你的研究

      Biorbyt has an extensive range of small molecules and antibodies available as research reagents to target proteins in the JAK/STAT pathways. We provide the best service and a simple buying process allowing you to focus on your valuable research. Take a look at our product pages where you will find competitive pricing, lead times, and easy delivery options. If you have any questions, just ask us.

        Biorbyt拥有广泛的小分子和抗体，可用作研究试剂以在JAK / STAT途径中靶向蛋白质。 我们提供最好的服务和简单的购买流程，让您专注于您的宝贵研究。 请查阅我们的产品页面，您可以找到具有竞争力的价格，交货期和易于交付的选项。 如果您有任何问题，请随时联系我们。

 

JAK/STAT信号通路 精品抗体

Catalogue Number	Product name	Clonality / Source	Applications
orb6210	IL6 antibody	Rabbit polyclonal	IF/ICC, IHC-P, P-ELISA, WB
orb69204	EGF antibody	Mouse monoclonal	FACS, IF/ICC, IHC-P, WB, ELISA
orb348869	EGFR antibody	Human monoclonal	IF/ICC, IHC-P, WB
orb379158	Ras antibody	Rabbit polyclonal	WB, IHC-P, IF/ICC, FACS
orb106105	PI3K p85 (phospho-Tyr458) antibody	Rabbit polyclonal	ELISA, IF/ICC, IHC-P, WB, IHC-fr
orb11393	SOCS3 antibody	Rabbit polyclonal	IHC-P, P-ELISA, WB
orb69334	STAT3 antibody	Mouse monoclonal	FACS, IF/ICC, IHC-P, WB, ELISA
orb344403	Akt (phospho-S473) antibody	Mouse monoclonal	FACS, IF/ICC, IHC-P, WB, ELISA
orb14690	SHP1 antibody	Rabbit polyclonal	IF/ICC, IHC-P, WB
orb166906	ERK1/2 antibody	Mouse monoclonal	WB, ELISA

 

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