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Catalog Number | orb1961084 |
---|---|
Category | Small Molecules |
Description | CLEC2D Protein, Mouse, Recombinant (His) |
Purity | 98.00% |
MW | 24-32 KDa, reducing conditions |
Biological Activity | C-type lectin domain family 2, member D (CLEC2D) is implicated in the immune response. Sensing tissue damage is an ancient function of immune cells that is central to the regulation of inflammation, tissue repair, and immunity. The C-type lectin receptor Clec2d as a sensor of cell death, which directly detects histones released during necrosis and thus contributes to inflammation and immunopathology. The Clec2d pathway may also be exploited to favor a pro-inflammatory anti-tumor response. And tumor cells can show reduced global levels of histone modification, which may favor Clec2d sensing. The contrasting expression of CLEC2D in HIV infection and pre-eclampsia is demonstrative of the immunosuppressive and pro-inflammatory roles of the respective pathologies. |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
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