Cholesterol

SKU: orb1310316

Description

Cholesterol

Research Area

Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 57-88-5
• MW: 386.65
• Purity: 99.85%
• Formula: C₂₇H₄₆O
• SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(=CC3)C[C@@H](O)CC4)(CC1)[H])[H])(CC[C@@]2([C@@H](CCCC(C)C)C)[H])[H]
• Target: Estrogen Receptor/ERR,Liposome,Antibacterial,ROR,Endogenous Metabolite,MRP
• Solubility: H2O:< 1 mg/mL (insoluble);Ethanol:11.42 mg/mL (29.54 mM);DMSO:< 1mg/mL (insoluble)

Bioactivity

• In Vivo:
  METHODS: To induce hypercholesterolemia, STD:ddY mice were fed a high cholesterol diet (1% cholesterol, 0.5% cholic acid, 0.5% olive oil and 93% s andard mouse chow). Results: Cholesterol can be used to construct a mouse model of hypercholesterolemia. METHODS: To induce hyperlipidemia, CD-1 mice were fed a high cholesterol diet (2% cholesterol and 0.6% sodium deoxycholate). Results: Cholesterol can be used to construct a mouse model of hyperlipidemia.
• In Vitro:
  METHODS: CD4+ T lymphocytes were incubated with 7-KC (17.5-70 µM) and Cholesterol-MβCD (17.5-70 µM) for 10 min, and T cell membrane order and disorder were assessed using di-4 ANEPPDHQ fluorescent dye. Results: After exposure to 7-KC, T cell membrane order was altered in a dose-dependent manner, with significant reconstitution of membrane order observed only in cells treated with 35 µM Cholesterol, while reconstitution with l7.5 µM Cholesterol induced minimal effects. METHODS: Human gastric cancer cells SNU601, SNU638 and SNU216 were treated with Cholesterol (25-100 µM) for 48 h and cell viability was measured using MTT Assay. Results: Cholesterol caused a dose-dependent decrease in cell viability in All three cell lines.

Storage & Handling

• Storage: store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

signaling, phosphorylation, RORα, SREBP2, transporters, unesterified, inhibit, MRP1, IRS-1, insulin, Inhibitor, Endogenous Metabolite, EndogenousMetabolite, exocytic, ERR, ERRα, Estrogen Receptor, EstrogenReceptor, Estrogen Receptor/ERR, Diabetes, Cholesteryl alcohol, Cholesterin, Cholesterol, AKT

Chemical structure of orb1310316

Compound Identifiers

PubChem CID

304