Chemerin/RARRES2 Protein, Human, Recombinant (His)

Catalog Number: orb1961046

Catalog Number	orb1961046
Category	Small Molecules
Description	Chemerin/RARRES2 Protein, Human, Recombinant (His)
Purity	98.00%
MW	16-20 KDa, reducing conditions
Biological Activity	Retinoic acid receptor responder protein 2(RARRES2) is a secreted protein that in humans is encoded by the RARRES2 gene. It is highly expressed in skin, also found in pancreas, liver, spleen, prostate, ovary, small intestine and colon. It is a chemoattractant protein that acts as a ligand for the G protein-coupled receptor CMKLR1. RARRES2 is secreted in an inactive form as prochemerin and is activated through cleavage of the C-terminus by inflammatory and coagulation serine proteases. It is thought to act as a cell surface receptor, found to stimulate chemotaxis of dendritic cells and macrophages to the site of inflammation. RARRES2 is inhibited in psoriatic lesions,it is activated by tazarotene in skin rafts and in the epidermis of psoriatic lesions.
Note	For research use only
Expiration Date	12 months from date of receipt.

Purity:	≥90% as determined by SDS-PAGE
Source:	This protein contains the human RARRES2(Glu21-Ser157) was fused with the C-terminal His Tag and expressed in Mammalian cells.