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Chelerythrine

SKU: orb1222344

Description

Chelerythrine may have antimanic effect . Chelerythrine can inhibit telomerase activity. Chelerythrine is a well-known protein kinase C inhibitor.Chelerythrine has potential antiproliferative and antitumor effects.

Images & Validation

Key Properties

CAS Number34316-15-9
MW348.37
Purity>98% (HPLC)
FormulaC21H18NO4+
SMILESC[N+]1=C2C(=C3C=CC(=C(C3=C1)OC)OC)C=CC4=CC5=C(C=C42)OCO5
TargetPDE

Bioactivity

In Vivo
Animal model: Unilateral ureteral obstruction (UUO) induced neonatal rats. Dosage: 5 mg/kg. Administration: i.p. , daily. Result: Attenuated kidney injury (Increased kidney weight and restored renal function). Inhibited UUO-induced upregulated kidney injury molecule-1 expression, apoptosis, and renal fibrosis.
In Vitro
Western blot analysis. Cell line: A549 and NCI-H1299 cells. Concentration: 10, 15, 20 μM. Incubation time: 24 h. Result: Induced expression of LC3-II in a beclin 1-dependent way.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information

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