CGP 35348

SKU: orb1306196

Description

CGP 35348 is a selective GABAB receptor antagonist (EC50 = 34 µM). It is utilized in neuroscience research to investigate mechanisms of synaptic transmission and has been applied in studies examining neuromuscular coordination and spatial learning deficits in murine models of neonatal brain injury.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 123690-79-9
• MW: 225.22
• Purity: 99.92% (May vary between batches)
• Formula: C₈H₂₀NO₄P
• SMILES: C(P(CCCN)(=O)O)(OCC)OCC
• Target: GABA Receptor
• Solubility: DMSO:< 2.25 mg/mL (10 mM, insoluble or slightly soluble);H2O:41.66 mg/mL (184.97 mM)

Bioactivity

• In Vivo:
  In male Wistar rats, CGP 35348(100, 300, and 900 mg/kg) produced an increase in the duration of non-REM sleep and rapid eye movement (REM) sleep and reduced strongly spike-wave discharges.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

centrally, CGP35348, CGP-35348, CGP 35348, brain penetrant, active, Gamma-aminobutyric acid Receptor, GABAB, GABAReceptor, GABA Receptor, Inhibitor, inhibit, neuromuscular, neonatal damage, γ-Aminobutyric acid Receptor, spatial learning

Compound Identifiers

PubChem CID

107699