CDPPB

SKU: orb1305863

Description

CDPPB is a potent positive allosteric modulator of the human mGluR5 receptor, exhibiting an EC50 of 27 nM in recombinant CHO cell assays. It is widely used in neuroscience research to investigate mGluR5 function in vitro and in animal models of disorders such as schizophrenia and Fragile X syndrome.

Research Area

Cell Biology, Metabolism Research, Neuroscience, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 781652-57-1
• MW: 364.4
• Purity: 99.16% (May vary between batches)
• Formula: C₂₃H₁₆N₄O
• SMILES: O=C(Nc1cc(nn1-c1ccccc1)-c1ccccc1)c1cccc(c1)C#N
• Target: Mitochondrial Metabolism,Akt,ERK,GluR,Caspase
• Solubility: DMSO:3.65 mg/mL (10.02 mM)

Bioactivity

• Target IC50:
  mGluR5:27 nM (EC50)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CDPPB, antipsychotic, allosteric, Metabotropic glutamate receptors, metabotropic, mGluR, mGluR5, inhibit, glutamate, Inhibitor, receptor, positive, subtype

Compound Identifiers

PubChem CID

11245456