CDK5-IN-3

SKU: orb2664828

Description

CDK5-IN-3 is a selective and potent CDK5 inhibitor that inhibits CDK5/p25 and CDK2/CycA and can be used in the study of cancer.

Research Area

Cell Biology

Key Properties

• CAS Number: 2639542-32-6
• MW: 362.47
• Purity: 98.21%
• Formula: C₂₂H₂₆N₄O
• SMILES: [C@](C)(O)(C1=NC2=C(C=C1)C=NC(NC3=CC=CC=C3)=C2)[C@H]4CCN(C)CC4
• Target: CDK
• Solubility: DMSO:8 mg/mL (22.07 mM)

Bioactivity

• Target IC50:
  CDK2-CyclinA:18 nM|CDK5-p25:0.6 nM
• In Vitro:
  CDK5-IN-3 is a potent and selective CDK5 inhibitor with IC50 values of 0.6 nM and 18 nM for CDK5/p25 and CDK2/CycA, respectively. CDK5-IN-3 can be used in the study of autosomal dominant polycystic kidney disease (ADPKD).

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CDK5

Compound Identifiers

PubChem CID

156212722