CDK5-IN-3

SKU: orb2664828

Description

CDK5-IN-3 is a potent and selective inhibitor targeting the CDK5/p25 and CDK2/CycA complexes. Its application in cancer research includes in vitro studies demonstrating effects on cell proliferation and in vivo models exploring its potential in neuroblastoma and glioblastoma.

Research Area

Cell Biology

Key Properties

• CAS Number: 2639542-32-6
• MW: 362.47
• Purity: 98.21% (May vary between batches)
• Formula: C₂₂H₂₆N₄O
• SMILES: [C@](C)(O)(C1=NC2=C(C=C1)C=NC(NC3=CC=CC=C3)=C2)[C@H]4CCN(C)CC4
• Target: CDK
• Solubility: DMSO:8 mg/mL (22.07 mM)

Bioactivity

• Target IC50:
  CDK2-CyclinA:18 nM|CDK5-p25:0.6 nM
• In Vitro:
  CDK5-IN-3 is a potent and selective CDK5 inhibitor with IC50 values of 0.6 nM and 18 nM for CDK5/p25 and CDK2/CycA, respectively. CDK5-IN-3 can be used in the study of autosomal dominant polycystic kidney disease (ADPKD).

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CDK5

Compound Identifiers

PubChem CID

156212722