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Catalog Number | orb1959682 |
---|---|
Category | Proteins |
Description | Tumor metastasis depends on the dynamic regulation of cell adhesion through β1-integrin. The Cub-Domain Containing Protein-1, CDCP1, is a transmembrane glycoprotein which regulates cell adhesion. Overexpression and loss of CDCP1 have been observed in the same cancer types to promote metastatic progression. CDCP1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 73.2 kDa and the accession number is F6TPM5. |
Tag | C-His |
Purity | 98.00% |
MW | 73.2 kDa (predicted). Due to glycosylation, the protein migrates to 80-115 kDa based on Tris-Bis PAGE result. |
UniProt ID | F6TPM5 |
Expression System | HEK293 Cells |
Biological Origin | Cynomolgus |
Biological Activity | Tumor metastasis depends on the dynamic regulation of cell adhesion through β1-integrin. The Cub-Domain Containing Protein-1, CDCP1, is a transmembrane glycoprotein which regulates cell adhesion. Overexpression and loss of CDCP1 have been observed in the same cancer types to promote metastatic progression. CDCP1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 73.2 kDa and the accession number is F6TPM5. |
Expression Region | Ala29-Thr667 |
Storage | -20°C |
Note | For research use only |
Application notes | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
Expiration Date | 6 months from date of receipt. |
The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining. | |
The protein has a predicted molecular mass of 73.4 kDa after removal of the signal peptide. The apparent molecular mass of cCDCP1-His is approximately 100-130 kDa due to glycosylation. | |
Mammalian |
98.00% | |
75 kDa (predicted). Due to glycosylation, the protein migrates to 90-115 kDa based on Tris-Bis PAGE result. |