CD80 Antibody

• Catalog Number: orb386038
• Category: Antibodies
• Description: T cell proliferation and lymphokine production are triggered by occupation of the TCR by antigen, followed by a costimulatory signal that is delivered by a ligand expressed on antigen presenting cells. The B7-related cell surface proteins CD80 (B7-1) and CD86 (B7-2) are expressed on antigen presenting cells bind the homologous T cell receptors CTLA-4 (cytotoxic T lymphocyte-associated protein-4) and CD28 and trigger costimulatory signals for optimal T cell activation. CTLA-4 shares 31% overall amino acid identity with CD28 and it has been proposed that CD28 and CTLA-4 are functionally redundant. SLAM is a novel receptor on T cells that, when engaged, potentiates T cell expansion in a CD28-independent manner. B7, also designated BB1, is another ligand or counter receptor for CD28 and CTLA-4 that is expressed on the antigen-presenting cell.
• Clonality: Monoclonal
• Species/Host: Mouse
• Isotype: Mouse IgG1, kappa
• Conjugation: Unconjugated
• Reactivity: Human
• Immunogen: Recombinant human protein used as the immunogen for the CD80 antibody.
• UniProt ID: P33681
• Tested applications: ELISA
• Dilution range: ELISA (order BSA/sodium azide-free format for coating)
• Application notes: Titering of the Galectin 13 antibody may be required for optimal performance.
• Antibody Type: Primary Antibody
• Clone Number: C80/1608
• Formula: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Hazard Information: This CD80 antibody is available for research use only.
• Note: For research use only

SDS-PAGE analysis of purified, BSA-free CD80 antibody (clone C80/1608) as confirmation of integrity and purity.