CD64 antibody

• Catalog Number: orb613911
• Category: Antibodies
• Description: Human monoclonal antibody to CD64
• Species/Host: Human
• Clonality: Monoclonal
• Clone Number: H22
• Tested applications: ELISA, FC
• Reactivity: Human
• Isotype: IgG1
• Immunogen: This recombinant antibody was prepared by cloning the single chain fragment (scFv) derived from the murine anti-human CD64 mAb m22 into the bacterial expression vector pBM1.1, and fusing it to a deletion mutant of Pseudomonas exotoxin A (ETA'􏳑).
• Concentration: 1 mg/ml
• Purity: Purified
• Conjugation: Unconjugated
• Target: CD64
• UniProt ID: P12314
• Storage: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
• Buffer/Preservatives: PBS with 0.02% Proclin 300.
• Alternative names: Anti-High affinity immunoglobulin gamma Fc recepto
• Note: For research use only
• Application notes: This immunotoxin binds human CD64, and displays specific cytotoxicity against, and thus can be used to selectively eliminate, AML cells; FC analysis indicated that this immunotoxin drove 41% of primary leukemia cells from a patient with CD64-positive AML into early apoptosis (Tur, 2003). Similarly, in an in vivo mouse model, IHC analysis revealed efficient elimination of human CD64+ tumor cells in mouse organs (Tur, 2011).
• Expiration Date: 12 months from date of receipt.