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Catalog Number | orb1881228 |
---|---|
Category | Antibodies |
Description | CD170, also known as Siglec 5 (sialic acid binding Ig-like lectin 5) is a type 1 transmembrane glycoprotein containing two cytoplasmic immunoreceptor tyrosine inhibitory motifs (ITIMs). CD170 forms homodimers and functions as an inhibitory receptor able to downregulate cell activation. It binds to alpha2,3- and alpha2,6-linked sialic acid ligands, e.g. on glycophorin A (CD235a). Aberrant expression of CD170 by CD34+ progenitor cells can be observed in case of acute myeloid leukemias. |
Clonality | Monoclonal |
Clone Number | 1A5 |
Tested applications | FC |
Reactivity | Human, Primate |
Isotype | Mouse IgG1 |
Immunogen | Fusion protein composed of human CD170 extracellular domain and Fc region of human IgG1 |
Conjugation | APC |
Target | CD170 |
Entrez | 8778 |
UniProt ID | O15389 |
Storage | Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze. |
Buffer/Preservatives | Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
Alternative names | OBBP2, OB-BP2, SIGLEC-5, SIGLEC5 Read more... |
Note | For research use only |
Application notes | Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests. |
Expiration Date | 12 months from date of receipt. |
Separation of human neutrophil granulocytes (red-filled) from CD170 negative lymphocytes (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CD170 (1A5) APC antibody (10 μl reagent / 100 μl of peripheral whole blood).
Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human CD170 (1A5) APC antibody (10 μl reagent / 100 μl of peripheral whole blood).
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