CD117 Antibody (PE/Cy5)

• Catalog Number: orb1993471
• Category: Antibodies
• Description: CD117 / c-Kit (stem cell factor receptor) is a 145 kDa receptor tyrosine kinase that regulates cell proliferation, adhesion, chemotaxis, apoptosis and other cell processes. Mutations of CD117 / c-Kit can lead to growth and progression of tumours. After binding of its ligand, SCF (stem cell factor), CD117 / c-Kit is autophosphorylated on its intracellular domains and activated. CD117 is expressed on pluripotent hematopoietic progenitor cells, mast cells and various cancer cells, e.g. acute myeloid leukemia cells.
• Clonality: Monoclonal
• Clone Number: 104D2
• Tested applications: FC
• Reactivity: Bovine, Human, Primate
• Isotype: Mouse IgG1 kappa
• Immunogen: MOLM-1 megakaryocytic cells
• Conjugation: PE/Cy5
• Target: CD117
• Entrez: 3815
• UniProt ID: P10721
• Storage: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
• Buffer/Preservatives: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• Alternative names: c-Kit, PBT, SCFR
• Note: For research use only
• Application notes: Flow cytometry: The reagent is designed for analysis of human blood cells using 4 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.
• Expiration Date: 12 months from date of receipt.