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Catalog Number | orb1909791 |
---|---|
Category | Antibodies |
Description | CD105 (endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels. |
Clonality | Monoclonal |
Clone Number | MEM-229 |
Tested applications | FC |
Reactivity | Human, Porcine |
Isotype | Mouse IgG2a |
Immunogen | Recombinant Vaccinia virus containing the human CD105 (L-isoform) cDNA. |
Conjugation | APC |
Target | CD105 |
Entrez | 2022 |
UniProt ID | P17813 |
Storage | Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze. |
Buffer/Preservatives | Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
Alternative names | Endoglin, END, ENG, HHT1, ORW1 Read more... |
Note | For research use only |
Application notes | Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests. |
Expiration Date | 12 months from date of receipt. |
Separation of HUVEC cells stained using anti-human CD105 (MEM-229) APC antibody (10 μl reagent per million cells in 100 μl of cell suspension, red-filled) from HUVEC cells stained using mouse IgG2a isotype control (MOPC-173) APC antibody (concentration in sample 5 μg/ml, same as CD105 APC concentration, black-dashed) in flow cytometry analysis (surface staining).
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