CCR1 antagonist 12

SKU: orb2646270

Description

CCR1 antagonist12 (Compound 12) is a potent small molecule antagonist of human CCR1 (IC50 = 3 nM), effectively inhibiting CCL3-induced chemotaxis (IC50 = 9 nM). It displays favorable pharmacokinetics in rats, making it a valuable tool for in vitro and in vivo research into inflammatory and autoimmune diseases mediated by CCR1 signaling.

Research Area

Immunology & Inflammation, Immunology & Inflammation; Pharmacology & Drug Discovery, Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 921208-19-7
• MW: 487.95
• Formula: C₂₅H₂₇ClFN₃O₄
• SMILES: O=C(C=CC1=CC(OC)=C(Cl)C=C1NC(=O)C)N2CC3N(CC4=CC=C(F)C=C4)C(COC3)C2
• Target: CCR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

69382179