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CCL2 Protein, Human, Recombinant
Catalog Number: orb1962201
| Catalog Number | orb1962201 |
|---|---|
| Category | Proteins |
| Description | The chemokine (C-C motif) ligand 2 (CCL2), also known as monocyte chemoattractant protein (MCP)-1 and small inducible cytokine A2 (SCYA2)), is a small cytokine that belongs to the CC chemokine family responsible for monocyte attraction. Its cognate receptor, CCR2, play a critical role in regulating nociceptive processes during neuropathic pain. Both CCL2 and CCR2 are implicated in induction of autoimmunity. CCL2 recruits monocytes, memory T cells, and dendritic cells to the sites of inflammation produced by either tissue injury or infection. Recently research also showed that CCL2 might be useful as a biomarker of fibrosis as well as a target for therapeutic intervention. |
| Tag | Tag Free |
| Purity | 98.00% |
| Protein Sequence | Gln24-Thr99 |
| UniProt ID | P13500 |
| MW | 13 KDa (reducing condition) |
| Application notes | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Expression System | E. coli |
| Biological Origin | Human |
| Biological Activity | The chemokine (C-C motif) ligand 2 (CCL2), also known as monocyte chemoattractant protein (MCP)-1 and small inducible cytokine A2 (SCYA2)), is a small cytokine that belongs to the CC chemokine family responsible for monocyte attraction. Its cognate receptor, CCR2, play a critical role in regulating nociceptive processes during neuropathic pain. Both CCL2 and CCR2 are implicated in induction of autoimmunity. CCL2 recruits monocytes, memory T cells, and dendritic cells to the sites of inflammation produced by either tissue injury or infection. Recently research also showed that CCL2 might be useful as a biomarker of fibrosis as well as a target for therapeutic intervention. |
| Expression Region | Gln24-Thr99 |
| Storage | -20°C |
| Note | For research use only |
| Expiration Date | 6 months from date of receipt. |
- Item 1 of 1
Human CCL2 protein (Active) [orb359066]
> 96% as determined by SDS-PAGE and HPLC.
8.7 kDa
E.Coli
100 μg, 5 μg, 500 μg - Item 1 of 1
Recombinant Human Monocyte Chemotactic Protein-1/CCL2 [orb1906072]
> 96 % by SDS-PAGE and HPLC analyses.
Approximately 8.7 kDa, a single non-glycosylated polypeptide chain containing 76 amino acids.
Escherichia coli
500 μg, 5 μg, 100 μg - Item 1 of 1
- Item 1 of 1
Human CCL2 Protein, hFc Tag [orb1291052]
The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
The protein has a predicted molecular mass of 34.8 kDa after removal of the signal peptide. The apparent molecular mass of CCL2-hFc is approximately 35-55 kDa due to glycosylation.
Mammalian
100 μg, 50 μg, 10 μg - Item 1 of 1
Human MCP1 protein [orb603961]
Greater than 90% as determined by SDS-PAGE.
35.7 kDa
E.coli
20 μg, 100 μg, 1 mg
