CB-6644

SKU: orb1309867

Description

CB-6644 is a potent and selective small molecule inhibitor of the RUVBL1/2 complex ATPase activity, exhibiting an IC50 of 15 nM. It is a valuable chemical probe for investigating the roles of RUVBL1/2 in cancer biology, chromatin remodeling, and c-Myc signaling in both cellular and animal models.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 2316817-88-4
• MW: 573.06
• Purity: 100.00% (May vary between batches)
• Formula: C₂₉H₃₄ClFN₄O₅
• SMILES: CCOc1cc(F)c(Cl)cc1C(=O)NCC(C)(C)CC(=O)Nc1c(COC)n2CCCc3ccccc3-n2c1=O
• Target: Others
• Solubility: DMSO:49 mg/mL (85.51 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.75 mM)

Bioactivity

• Target IC50:
  RUVBL1/2:15 nM
• In Vivo:
  METHODS: Plasma concentrations and tumor growth were measured in nude female mice or after a single intravenous dose (0.5 mg/kg) of CB-6644. RESULTS CB-6644 can significantly inhibit tumor growth and has little effect on body weight.
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• In Vitro:
  METHODS: HCT116, NCI-1975, and HT29 cells were treated with CB-6644 (100nM-500nM) and allowed to form colonies within 3 weeks. RESULTS CB-6644 was able to effectively kill cells with an EC50 range of 41 ~ 785 nM.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, CB6644, CB-6644, CB 6644, RUVBL1/2

Compound Identifiers

PubChem CID

137333455