CB-103

SKU: orb1309326

Description

CB-103 is an orally bioavailable small molecule that potently inhibits the Notch signaling pathway. It has demonstrated anti-tumor activity in preclinical models, showing efficacy in both in vitro assays and in vivo studies targeting hematological and solid tumors.

Research Area

Neuroscience, Protein Biochemistry, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 218457-67-1
• MW: 242.32
• Purity: 99.69% (May vary between batches)
• Formula: C₁₅H₁₈N₂O
• SMILES: CC(C)(C)C1=CC=C(OC2=NC=C(N)C=C2)C=C1
• Target: Gamma-secretase
• Solubility: DMSO:50 mg/mL (206.34 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:2.5 mg/mL (10.32 mM)

Bioactivity

• In Vivo:
  CB-103inhibits growth of GSI/Mab resistant triple negative breast cancer, andexhibits anti-tumor activity in xenograft models of human T-ALL and mouse mammary tumors.
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• In Vitro:
  CB-103 has shown the ability to block NOTCH signaling in human T cell acute lymphoblastic leukemia cancer cell lines, and exhibits anti-tumor efficacy in GSI resistant T-ALL cell lines.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CB103, CB-103, CB 103, pathway, inhibit, Notch, Inhibitor, Gammasecretase, leukemia, signaling

Compound Identifiers

PubChem CID

2735289