CASP10 antibody

• Catalog Number: orb66964
• Category: Antibodies
• Description: Rabbit polyclonal to CASP10.Caspase 10 (CASP10) belongs to the peptidase C14A family, which is involved in the activationcascade of caspases responsible for apoptosis execution. CASP10 is recruited to both Fas-andTNFR-1 receptors in a FADD dependent manner, and may participate in the granzyme B apoptoticpathways. CASP10 cleaves and activates caspase-3, -4, -6, -7, -8, and -9, and hydrolyzes the smallmoleculesubstrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. Defects in CASP10 havebeen implicated in autoimmune lymphoproliferative syndrome type 2A (ALPS2A), familial non-Hodgkin lymphoma (NHL) and gastric cancer (GASC).
• Species/Host: Rabbit
• Clonality: Polyclonal
• Tested applications: WB
• Reactivity: Human
• Immunogen: middle region of human CASP10
• Dilution range: WB:1:1000-1:5000
• Purity: Affinity purification
• Conjugation: Unconjugated
• MW: 59
• UniProt ID: Q92851
• Storage: -20°C
• Buffer/Preservatives: 0.01% NaN3
• Alternative names: anti-CASP10 antibody,anti-Caspase10 antibody,anti-
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

Western blot analysis of total cell extracts from human Hela using CASP10 antibody