CARM1 antibody

• Catalog Number: orb67015
• Category: Antibodies
• Description: Rabbit polyclonal to CARM1.Coactivator-associated arginine methyltransferase 1 (CARM1) is also known as Protein arginine Nmethyltransferase4 (PRMT4), which catalyze the transfer of a methyl group from S-adenosyl-Lmethionineto the side chain nitrogens of arginine residues within proteins to form methylated argininederivatives and S-adenosyl-L-homocysteine. Protein arginine methylation has been implicated insignal transduction, metabolism of nascent pre-RNA, and transcriptional activation Methylates (monoandasymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involvedin DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. CARM1 isrecruited to promoters upon gene activation together with histone acetyltransferases fromEP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainlyasymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling.
• Species/Host: Rabbit
• Clonality: Polyclonal
• Tested applications: WB
• Reactivity: Human, Mouse
• Immunogen: C-terminal region of human CARM1
• Dilution range: WB:1:1000-1:5000
• Purity: Affinity purification
• Conjugation: Unconjugated
• MW: 66
• UniProt ID: Q86X55
• Storage: -20°C
• Buffer/Preservatives: 0.01% NaN3
• Alternative names: anti-CARM1 antibody,anti-Histonearginine methyltra
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

Western blot analysis of total cell extracts from mouse MEF using CARM1 antibody