You have no items in your shopping cart.
You have no items in your shopping cart.
Catalog Number | orb1184772 |
---|---|
Category | Proteins |
Description | V-set domain-containing T-cell activation inhibitor 1 (VTCN1) is also known as Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7H4, which belongs to the immunoglobulin superfamily and BTN/MOG family. VTCN1 contains two Ig-like V-type (immunoglobulin-like) domains. The expression of VTCN1 is up-regulated by IL6 and IL10 and is inhibited by GM-CSF and IL4 on antigen-presenting cells (APCs). VTCN1 / B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. VTCN1 involved in promoting epithelial cell transformation. |
Reactivity | Canine |
Tag | C-10×His |
Form/Appearance | Powder |
Purity | 90% |
Conjugation | Unconjugated |
MW | 27.2 kDa |
Target | B7-H4 |
Protein Sequence | XP_038547815.1 |
Source | Canine B7-H4, His Tag (orb1184772) is expressed from human 293 cells (HEK293). It contains AA Phe 29 - Ala 258 (Accession # XP_038547815.1). |
Expression System | HEK293 |
Expression Region | Phe 29 - Ala 258 |
Endotoxins | 1.0 EU per μg |
NCBI | XP_038547815.1 |
Storage | -20℃ |
Buffer/Preservatives | PBS, pH7.4 |
Alternative names | B7-H4,VTCN1,B7S1,B7h.5 Read more... |
Note | For research use only |
Application notes | This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 27.2 kDa. The protein migrates as 44-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Expiration Date | 6 months from date of receipt. |
Filter by Rating