Brevican antibody

• Catalog Number: orb150305
• Category: Antibodies
• Description: Mouse monoclonal to Brevican (HRP). Brevican is the most abundant chondroitin sulfate proteoglycan in the extracellular matrix of the adult brain. It is a member of the lectican family of aggregating extracellular matrix proteoglycans that bear chondroitin sulfate (CS) chains. It is highly expressed in the central nervous system and is thought to stabilize synapses and inhibit neural plasticity. Brevican is secreted from astrocytes and neurons as a 145 kD core protein that bears up to three, covalently-linked, CS chains. It is also is secreted as a 145 kD core protein without CS chains. When cleaved by extracellular glutamyl endopeptidases, the ADAMTSs, a 55 kD N-terminal fragment is formed that contains the unique C terminal epitope EAMESE..
• Species/Host: Mouse
• Clonality: Monoclonal
• Clone Number: S294A-6
• Tested applications: ICC, WB
• Reactivity: Human, Mouse, Rat
• Isotype: IgG2B
• Immunogen: Fusion protein amino acids 219-655 of rat Brevican
• Concentration: 1 mg/ml
• Dilution range: WB (1:1000)
• Conjugation: HRP
• MW: 140kDa
• Target: Brevican
• Entrez: 25393
• UniProt ID: P55068
• NCBI: NP_001028837.1
• Storage: Conjugated antibodies should be stored at 4°C
• Buffer/Preservatives: PBS pH 7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
• Alternative names: BCAN antibody, BEHAB antibody, CSPG7 antibody, Bra
• Note: For research use only
• Application notes: 1 µg/ml of SMC-428 was sufficient for detection of Brevican in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
• Expiration Date: 12 months from date of receipt.