BPK-29 hydrochloride

SKU: orb1308857

Description

BPK-29 hydrochloride is a covalent inhibitor targeting cysteine 274 of the orphan nuclear receptor NR0B1, disrupting its protein-protein interactions. This small molecule is a valuable research tool for studying NR0B1 function and has been shown to inhibit anchorage-independent growth in KEAP1-mutant cancer cell lines in vitro.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 2444815-73-8
• MW: 506.46
• Purity: 99.19% (May vary between batches)
• Formula: C₂₆H₃₃Cl₂N₃O₃
• SMILES: Cl.ClCC(=O)N(Cc1ccccc1)C1CCCN(CC1)C(=O)c1ccc(cc1)N1CCOCC1
• Target: Others,Nrf2
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.95 mM);DMSO:62.5 mg/mL (123.41 mM)

Bioactivity

• In Vitro:
  BPK-29 substantially engages NR0B1 with good overall proteomic selectivity in KEAP1-mutant Non-Small Cell Lung Cancers.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BPK 29, BPK 29 Hydrochloride, BPK 29 hydrochloride, BPK29, BPK-29, BPK29 hydrochloride, BPK29 Hydrochloride, BPK-29 Hydrochloride, Inhibitor, inhibit

Compound Identifiers

PubChem CID

139035041