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BPIFB1 Antibody / LPLUNC1
Catalog Number: orb2637033
| Catalog Number | orb2637033 |
|---|---|
| Category | Antibodies |
| Description | The upper respiratory tract is the main place of entry for pathogens to invade the body, and early recognition of bacterial products in this region is crucial for host defense. Palate lung nasal epithelial clone PLUNC (or LUNX) is an airway specific secretory protein that is expressed in epithelial tissues and submucosal glands of the oral cavity and upper respiratory tract of humans, mice, rats and cows. PLUNC binds to lipopolysaccharide (LPS) in nasal lavage fluid (NLF) which points to its role in the inflammatory response of the upper airways after exposure to irritants. Decreased levels of PLUNC occur in the NLF of smokers and people who have been exposed to reactive epoxy chemicals, indicating that long-term exposure to airway irritants impairs the production of PLUNC in the upper respiratory tract. Abnormal expression of PLUNC may influence susceptibility to nasopharyngeal carcinoma in the Chinese population. |
| Species/Host | Mouse |
| Clonality | Monoclonal |
| Clone Number | LPLUNC1/3206 |
| Tested applications | ELISA, IHC-P, WB |
| Reactivity | Human |
| Isotype | Mouse IgG |
| Immunogen | Recombinant full-length human BPIFB1/LPLUNC1 protein was used as the immunogen for the BPIFB1 antibody. |
| Antibody Type | Primary Antibody |
| Dilution range | ELISA (order BSA-free format for coating),Western blot: 1-2ug/ml,Immunohistochemistry (FFPE): 1-2ug/ml |
| Purity | Protein A/G affinity |
| Conjugation | Unconjugated |
| Formula | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide |
| Hazard Information | This BPIFB1 antibody is available for research use only. |
| UniProt ID | Q8TDL5 |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Buffer/Preservatives | 0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin (US sourced), 0.05% sodium azide |
| Note | For research use only |
| Application notes | Optimal dilution of the BPIFB1 antibody should be determined by the researcher. |
| Expiration Date | 12 months from date of receipt. |
IHC staining of FFPE human breast carcinoma tissue with BPIFB1 antibody (clone LPLUNC1/3206). HIER: boil tissue sections in pH9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
IHC staining of FFPE human breast carcinoma tissue with BPIFB1 antibody (clone LPLUNC1/3206). HIER: boil tissue sections in pH9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
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