BMP signaling agonist sb4

SKU: orb1299495

Description

BMP signaling agonist sb4

Research Area

Stem Cell & Developmental Biology

Key Properties

• CAS Number: 100874-08-6
• MW: 320.2
• Purity: 99.24%
• Formula: C₁₄H₁₀BrNOS
• SMILES: Brc1ccc(CSc2nc3ccccc3o2)cc1
• Target: TGF-beta/Smad
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.12 mM);DMSO:10 mg/mL (31.23 mM)

Bioactivity

• Target IC50:
  BMP:74 nM(EC50)
• In Vitro:
  SB4, that rapidly stimulated BMP signaling in these cells. Activation of BMP signaling by sb4 increased the phosphorylation of key second messengers (SMAD-1/5/9) and also increased expression of direct target genes (inhibitors of DNA binding, Id1 and Id3) in canonical BMP signaling.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

agonist, bmp, BMP signaling agonist sb 4, BMP signaling agonist sb4, BMP signaling agonist sb-4, bone morphogenetic protein (BMP), BRE-luc, SB4, SB-4, SB 4, Smad, SMAD, TGFbeta/Smad, TGF-beta, TGFbeta, TGF-β Receptor, TGF-β/Smad, TGFβ, TGFb, TGF-b/Smad, PREC, Transforming growth factor beta receptors

Compound Identifiers

PubChem CID

731364