Bitertanol

SKU: orb1305172

Description

Bitertanol

Research Area

Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 55179-31-2
• MW: 337.42
• Purity: 99.56% (May vary between batches)
• Formula: C₂₀H₂₃N₃O₂
• SMILES: C(OC1=CC=C(C=C1)C2=CC=CC=C2)(C(C(C)(C)C)O)N3C=NC=N3
• Target: Cytochromes P450,Antifungal
• Solubility: DMSO:12 mg/mL (35.56 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:1 mg/mL (2.96 mM)

Bioactivity

• In Vivo:
  Bitertanol (10, 25, and 100 mg/kg) produced 2-, 4-, and 14-fold increases of 7-ethoxyresorufin O-deethylation activity in liver microsomes, respectively. Bitertanol (25 mg/kg) increased CYP1A1 protein in the liver, kidney, and lung by 10-, 13-, and 17-fold, respectively. Bitertanol produced smaller increases of CYP2B and CYP3A catalytic activity and protein than that of CYP1A1 in liver. Additions of 0.01-100 microM Bitertanol to liver microsomes from rats Bitertanol (25 mg/kg) inhibited microsomal 7-ethoxyresorufin O-demethylation activity (IC50=0.8 microM). Bitertanol (100 mg/kg) increased liver UDP-glucuronosyltransferase and glutathione S-transferase activities by 2-fold. Bitertanol (25 mg/kg) produced a minor increase in metabolic activation of benzo[a]pyrene by liver S-9 fraction in the Ames mutagenicity test while the increase was blocked by addition of 100 microM Bitertanol.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

KWG 0599, KWG0599, KWG-0599, Bitertanol, Biloxazol, Baycor, Antifungal, Sibutol

Compound Identifiers

PubChem CID

91656