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Catalog Number | orb762452 |
---|---|
Category | Proteins |
Description | Transforming growth factor beta 3 ( TGFB3) is also known as TGF-β3, is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development. TGF-beta 3 is similar with TGF-beta 1 and -beta 2, act as cellular switches to regulate immune function, cell proliferation, and epithelial-mesenchymal transition. TGF-beta-3 is released from LAP by integrins: integrin-binding results in distortion of the LAP chain and subsequent release of the active TGF-beta-3. Once activated following release of LAP, TGF-beta-3 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal. |
Reactivity | Human |
Tag | N-10×His & C-Avi |
Form/Appearance | Powder |
Purity | 90% |
Conjugation | Biotin |
MW | 48.4 kDa |
Target | TGF-beta 3 |
Protein Sequence | NP_003230.1 |
Source | Biotinylated Human Latent TGFB3, His, (orb762452) is expressed from human 293 cells (HEK293). It contains AA Leu 24 - Ser 412 (Accession # P10600-1). |
Expression System | HEK293 |
Expression Region | Leu 24 - Ser 412 |
Endotoxins | 1.0 EU per μg |
NCBI | NP_003230.1 |
Storage | -20℃ |
Buffer/Preservatives | PBS, pH7.4 |
Alternative names | TGFB3,ARVD,TGF-beta3 Read more... |
Note | For research use only |
Application notes | This protein carries a polyhistidine tag at the N-terminus and an Avi tag () at the C-terminus. The protein has a calculated MW of 48.4 kDa. The protein migrates as 40-45 kDa and 60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Expiration Date | 6 months from date of receipt. |
98.00% | |
12&37-45 KDa, reducing conditions |
98.00% | |
The protein has a predicted MW of 45.9 kDa. Due to enzyme lysis and glycosylation, the protein migrates to 43-48 kDa and 50-60 kDa based on Tris-Bis PAGE result. |
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