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Catalog Number | orb1496267 |
---|---|
Category | Proteins |
Description | Herpesvirus entry mediator (HVEM) is also known as TNFRSF14, TR2 (TNF receptorlike molecule) and ATAR (another TRAF associated receptor), is a type I membrane protein belonging to the TNF/NGF receptor superfamily. HVEM expression has been detected in peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells. The extracellular domain of HVEM has been shown to interact directly with the herpes simplex virus envelope glycoprotein D (gD). Two TNF superfamily ligands, including the secreted TNFβ (lymphotoxin α) and the membrane protein LIGHT (lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes), have been shown to be the cellular ligands for HVEM. Besides HVEM, LIGHT can also interact with LTβR, the receptor for lymphotoxin αβ heterotrimer. The role of the HVEM LIGHT /LTβ receptor ligand pair in immune function and herpesvirus pathobiology remains to be elucidated. |
Reactivity | Human |
Tag | C-Fc & C-Avi |
Form/Appearance | Powder |
Purity | 95% |
Conjugation | Biotin |
MW | 45.5 kDa |
Target | HVEM |
Protein Sequence | Leu 39 - Val 202 |
Source | Biotinylated Human HVEM, Fc, (orb1496267) is expressed from human 293 cells (HEK293). It contains AA Leu 39 - Val 202 (Accession # Q92956-1). |
Expression System | HEK293 |
Expression Region | Leu 39 - Val 202 |
Endotoxins | 1.0 EU per μg |
Storage | -20℃ |
Buffer/Preservatives | 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 |
Alternative names | TNFRSF14,ATAR,HVEA,HVEM,LIGHTR,TR2,CD270 Read more... |
Note | For research use only |
Application notes | This protein carries a human IgG1 Fc tag at the C-terminus, followed by an Avi tag (). The protein has a calculated MW of 45.5 kDa. The protein migrates as 55-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Expiration Date | 6 months from date of receipt. |
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