Biotinylated Human GCGR / Glucagon receptor Protein, His, (MALS verified)

• Catalog Number: orb1499255
• Category: Proteins
• Description: G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.
• Reactivity: Human
• Form/Appearance: Powder
• Purity: 90%
• Conjugation: Biotin
• MW: 16.6 kDa
• Target: GCGR
• UniProt ID: P47871
• Source: Biotinylated Human GCGR Protein, His, (orb1499255) is expressed from human 293 cells (HEK293). It contains AA Ala 26 - Lys 136 (Accession # P47871-1).
• Expression System: HEK293
• Expression Region: Ala 26 - Lys 136
• Endotoxins: 1.0 EU per μg
• Storage: -20°C
• Buffer/Preservatives: PBS, pH7.4
• Alternative names: Glucagon R, GCGR,Glucagon receptor
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (). The protein has a calculated MW of 16.6 kDa. The protein migrates as 27-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.