Beta Klotho Protein, Mouse, Recombinant (His)

Catalog Number: orb1959781

Catalog Number	orb1959781
Category	Proteins
Description	Beta-klotho (KLB) is a coreceptor required for endocrine fibroblast growth factor (FGF) 15/19 and FGF21 signaling in the brain. Klb is prominent within the hypothalamus, which is consistent with its metabolic functions, but diverse roles for Klb are now emerging. Central Klb expression is low but discrete and may govern FGF-targeted sites. Beta Klotho Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 109.91 kDa and the accession number is Q99N32-1.
Tag	C-His
Purity	SDS-PAGE: > 90%; SEC-HPLC: > 90%
UniProt ID	Q99N32
MW	109.91 kDa (predicted). Due to glycosylation, the protein migrates to 120-130 kDa based on Tris-Bis PAGE result.
Application notes	0
Expression System	HEK293 Cells
Biological Origin	Mouse
Biological Activity	Beta-klotho (KLB) is a coreceptor required for endocrine fibroblast growth factor (FGF) 15/19 and FGF21 signaling in the brain. Klb is prominent within the hypothalamus, which is consistent with its metabolic functions, but diverse roles for Klb are now emerging. Central Klb expression is low but discrete and may govern FGF-targeted sites. Beta Klotho Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 109.91 kDa and the accession number is Q99N32-1.
Expression Region	Phe53-Pro994
Storage	-20°C
Note	For research use only

Purity:	> 90% as determined by SDS-PAGE.
MW:	50.82 kDa