Benzamide

SKU: orb1222055

Description

Benzamide, an inhibitor of poly(ADP-ribose) polymerase, is a derivative of benzoic acid.

Key Properties

• CAS Number: 55-21-0
• MW: 121.14
• Purity: >98% (HPLC)
• Formula: C₇H₇NO
• SMILES: C1=CC=C(C=C1)C(=O)N
• Target: PARP
• Solubility: In Vitro: DMSO : 120 mg/mL (990.59 mM)

Bioactivity

• In Vivo:
  Benzamide (160 mg/kg; IP, 2 injection by a 4 h interval) attenuates the METH-induced dopamine depletions. Benzamide (160 mg/kg; IP, single dosage) has no acute effect on striatal dopamine metabolism and does not reduce body temperature. Animal model: C57B1/6N mice (intraperitoneal injection of METH at 2-h intervals; 4 injections of 5 mg/kg, 4 injections of 10 mg/kg, or 2 injections of 20 mg/kg). Dosage: 160 mg/kg. Administration: IP, 2 injection by a 4 h interval. Result: Partially and significantly attenuated the METH-induced dopamine depletions during the different METH treatment. Animal model: C57B1/6N mice. Dosage: 160 mg/kg. Administration: IP, single dosage. Result: Had no acute effect on striatal dopamine metabolism and did not reduce body temperature.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PARP