BAY80-6946

• Catalog Number: orb322186
• Category: Small Molecules
• Description: BAY80-6946
• CAS Number: 1032568-63-0
• Purity: ≥98%
• MW: 480.52
• SMILES: COc1c(ccc2c1N=C(N3C2=NCC3)NC(=O)c4cnc(nc4)N)OCCCN5CCOCC5
• Formula: C₂₃H₂₈N₈O₄
• Hazard Information: UN Number: Not dangerous goods
• Solubility (25°C): Due to its chemical nature, pure BAY80-6946 solid powder was found to have very low solubility in common organic solvents. This has been reported in the literature. User may use the following method as a reference when making stock solution: 2 mg BAY80-6946 is placed in a clear vial. To this vial, 10 µL 10% HCl is added. The vial is capped and shaken for a few seconds to allow HCl solution to wet the crystals of BAY80-6946. Then 90 µL water is added, and shaken for a few second, which will give a clear stock solution at 20 mg /mL. This solution can be further diluted using 0.5% HCl water solution. Pure BAY80-6946 has very low solubility, because of its chemical property, not because of the poor quality of our product. Molecule of BAY80-6946 contains several basic nitrogen atoms, after protonated by HCl, its solubility will be enhanced. For in vitro studies, 5 mmol/L stock solution of BAY 80-6946 (in dimethyl sulfoxide with 10 mmol/L trifluoroacetic acid) was used - see Mol Cancer Ther. 2013 Nov;12(11):2319-30.
• Storage: Storage Temp: -20°C
• Alternative names: Copanlisib
• Note: For research use only
• Expiration Date: 12 months from date of receipt.