AZD8055, Free Base

• Catalog Number: orb153601
• Category: Small Molecules
• Description: AZD8055 is also named as[CCG-168]. AZD8055 is a novel ATP-competitive and selective inhibitor of mammalian target of rapamycin (mTOR) kinase with an IC50 value of 0. 8 nM. It inhibits the phosphorylation of mTORC1 substrates p70S6K and 4E-BP1, mTORC2 substrate AKT, and downstream proteins. AZD8055 also blocked the chemotherapy-induced cell death promoted by ectopic wild-type p62. AZD8055 potently inhibits proliferation, induces autophagy and apoptosis in different cells. Up to 10 μM AZD8055 showed no significant activity against a panel of 260 kinases at concentrations.
• CAS Number: 1009298-09-2
• Note: For research use only
• Application notes: AZX
• Expiration Date: 12 months from date of receipt.

Chemical structure of AZD8055, Free Base

AZD8055, Free Base: AZD 8055, AZD-8055