AZD1283

• Catalog Number: orb1304100
• Category: Small Molecules
• Description: AZD1283
• CAS Number: 919351-41-0
• Purity: 99.62%
• MW: 470.54
• SMILES: C(#N)C1=C(N=C(C)C(C(OCC)=O)=C1)N2CCC(C(NS(CC3=CC=CC=C3)(=O)=O)=O)CC2
• Formula: C₂₃H₂₆N₄O₅S
• Biological Activity: AZD1283 is an effective P2Y12 receptor antagonist (EC50: 3.0 ug/kg/min, binding IC50: 11 nM). AZD1283 dose-dependently induced increases in blood flow and inhibition of ADP-induced platelet aggregation with antithrombotic ED50 values of 3.0 and 10 μg/kg/min, respectively. The doses induced the increase in bleeding time at 33 and 100 μg/kg/min for 3- and 13-fold, respectively. Thus, the therapeutic index (TI) was ≥10 for both compounds.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.