Azaperone

SKU: orb1300802

Description

Azaperone is a butyrophenone tranquilizer primarily used in veterinary medicine for its sedative and antiemetic properties. In research, it is applied in pharmacological studies of dopamine receptors and in experimental models requiring chemical restraint for in vivo procedures.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1649-18-9
• MW: 327.4
• Purity: 98.73%
• Formula: C₁₉H₂₂FN₃O
• SMILES: C(CCC(=O)C1=CC=C(F)C=C1)N2CCN(CC2)C3=CC=CC=N3
• Target: Dopamine Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.11 mM);DMSO:60 mg/mL (183.26 mM);Ethanol:32 mg/mL (97.74 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vivo:
  Azaperone eliminates fighting only for a few hours after it is administered, after which the behaviour of pigs treated with it is not different from that of non-tranquillized mixed pigs. Azaperone (2.2 mg/kg i.m.) reduces total fighting from 309.8 min for saline to 189.6 min in pigs. Azaperone (103.1 mg) combined with Butorphanol (69.3 mg) produces adequate muscle relaxation and apparently adequate analgesia for minor surgical interferences, including abdominal laparoscopy, in a white rhinoceros with chronic renal disease. Azaperone combined with Butorphanol and Medetomidine (BAM: 0.43 mg/kg Butorphanol, 0.36 mg/kg Azaperone, 0.14 mg/kg Medetomidine) results in a predictable onset of sedation, with a mean induction time to lateral recumbency of 9.8 min, in white-tailed deer. Azaperone combined with Butorphanol and Medetomidine (BAM: 0.43 mg/kg Butorphanol, 0.36 mg/kg Azaperone, 0.14 mg/kg Medetomidine) results in decreased heart rate and increased arterial partial pressure of carbon dioxide (PaCO2) in white-tailed deer. Azaperone (1.0 mg/kg) combined with Ketamine (15 mg/kg) and Climazolam (1.5 mg/kg) results in a significantly higher castration score, when administrated intranasally (IN) compared with intramuscularly (IM) in piglets, there is an association between castration score and room temperature in the IN group. Azaperone (1.0 mg/kg) combined with Ketamine (15 mg/kg) and Climazolam (1.5 mg/kg) results in higher heart rate in the IN group of piglets. Azaperone (1.0 mg/kg) combined with Ketamine (15 mg/kg) and Climazolam (1.5 mg/kg) results in higher respiratory rate and walking significantly faster in the IM group of piglets.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

R 1929, R1929, R-1929, Suicalm, Stresnil, NSC 170976, inhibit, NSC170976, NSC-170976, Inhibitor, Fluoperidol, Azaperone, Dopamine Receptor, Dopamine, DopamineReceptor

Compound Identifiers

PubChem CID

15443