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Catalog Number | orb315341 |
---|---|
Category | Small Molecules |
Description | AV-412(MP-412) is a potent dual inhibitor of EGFR and ErbB2(IC50=19 nM) tyrosine kinases, including the mutant EGFR(L858R IC50=0.51 nM, T790M IC50=0.79 nM); inhibits autophosphorylation of EGFR and ErbB2 with IC(50) of 43 and 282 nM, respectively. |
CAS Number | [451492-95-8] |
MW | 507 |
SMILES | O=C(C=C)NC1=CC2=C(NC3=CC=C(C(Cl)=C3)F)N=CN=C2C=C1C#CC(C)(C)N(CC4)CCN4C |
Formula | C27H28ClFN6O |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
Chemical structure of AV-412(MP-412)
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