ARN1468

• Catalog Number: orb1688781
• Category: Small Molecules
• Description: ARN1468
• CAS Number: 1381459-14-8
• Purity: 98%
• MW: 354.33
• SMILES: NC1=C(C=NN1C1=CC=C(OC(F)(F)F)C=C1)C(=O)C1CCNCC1
• Formula: C₁₆H₁₇F₃N₄O₂
• Biological Activity: ARN1468 (compound 5) is a highly effective orally active inhibitor of serpins. Inhibition of serpins activity by ARN1468 enables release of proteases, thereby reducing prion accumulation. ARN1468 demonstrates pronounced anti-prion effects in ScGT1 RML, ScGT1 22L, ScN2a RML, and ScN2a 22L cell lines, with EC 50 values of 8.64, 19.3, 11.2, and 6.27 μM [1].
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.